Društvena predavanja

Društvo redno vabi na predavanja priznanih tujih in domačih strokovnjakov s področja biokemije in molekularne biologije. Predavanja navadno potekajo v inštitucijah v Ljubljani, vabila pa člani društva prejemajo po e-pošti. Seznam društvenih predavanj od leta 2008 naprej je spodaj. Seznam vseh društvenih predavanj od leta 1986-2008 se nahaja tukaj (iz biltena ob petindvajseti obletnici delovanja Slovenskega biokemijskega društva).

Swirling your way into the plasma membrane: the pore-forming toxin Aerolysin

prof. F. Gisou van der Goot, Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL)
Velika predavalnice, Kemijski inštitut, četrtek, 04.04.2013 13.00

Pore-forming toxins are the largest class of bacterial toxins. Pore-forming proteins are however found in all kingdoms of life from bacteria to plants and mammals. The seminar will be divided into two parts. Since pore formation is a very ancient form of attack cells have developed means to respond to their permeabilizing effects. Recent findings related to cellular responses will be reported. The second, and major, part will be focused on the structure of Aerolysin, which is the founding member of a super-family of ß-pore forming toxins for which the pore structure is unknown. The mechanisms leading to biosynthetic folding into the soluble state will be discussed. We have also combined X-ray crystallography, cryo-electron microscopy (EM), molecular dynamics and computational modeling to determine the structures of aerolysin mutants in their heptameric forms, trapped at various stages of the pore formation process. A dynamic docking approach based on swarm intelligence was applied whereby the intrinsic flexibility of aerolysin extracted from new X-ray structures was utilized to fully exploit the cryo-EM spatial restraints. Using this integrated strategy, we obtained a radically new arrangement of the prepore conformation and a near-atomistic structure of the aerolysin pore, which is fully consistent with all biochemical data available so far. Upon transition from the prepore to pore, the aerolysin heptamer shows a unique concerted swirling movement, accompanied by a vertical collapse of the complex, ultimately leading to the insertion of a transmembrane ß-barrel. 


2018

  • 152. 22. maj, Biotehniška fakulteta v Ljubljani . prof. dr. Tigran (Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Canada):Volumetric properties of tetraplex nucleic acid structures.
  • 151. 11. maj, Biotehniška fakulteta v Ljubljani . prof. Graziana Guella (Fakulteta za Fiziko Univerze v Trentu, Italija):Modern approaches in lipids investigations.

2017

  • 148. 17. november, Kemisjki inštitut. prof. dr. Andre Matagne (University of Liege, Belgium):The role of active site flexible loops in catalysis and of zinc in conformational stability of Bacillus cereus 569/H/9 beta-lactamase.
  • 150. 17. oktober, Inštitut za biokemijo Medicinske fakultete v Ljubljani. Dr. Klementina fon Tacer (St. Judes Children Research Hospital, USA):From spermatogenesis to cancer: melanoma antigens (MAGEs).
  • 149. 25. september, Inštitut za biofiziko Medicinska fakulteta v Ljubljani. Dr. Henning Hermjakob (EMBL-EBI Hinxton (UK)):Discovering and linking public omics datasets using the Omics Discovery Index.
  • 146. 11. september, Inštitut Jožef Stefan. prof. dr. Anna-Elina Lehesjoki (University of Helsinki, Finland):Progressive myoclonus epilepsies - on the way to presicion medicine?.
  • 147. 11. september, Kemijski inštitut. prof. dr. Christian Eggeling (University of Oxford, UK):Lipid membrane bioactivity - new insights from advanced (super-resolution) optical microscopy.
  • 145. 6. julij, Inštitut Jožef Stefan. dr. Petr Maly (Češka akademija znanosti, Vestec, Češka):Novel protein binders derived from albumin binding domain scaffold useful in biomedical applications .
  • 144. 1. junij, Velika predavalnica Kemijskega inštituta. izr. prof. dr. Simon Sedej (Graz Medical University, Austria):Kako spermidin ščiti srce pred staranjem.
  • 143. 26. maj, Inštitut za biokemijo Medicinske fakultete v Ljubljani. prof. dr. Peter Guengerich (Vanderbildt University, Nashville, USA):New cytochrome P450 reactions with retinoids and steroids.
  • 142. 10. maj, Seminarska soba fizike 106 Inštitut Jožef Stefan. dr. Annabell Varrot (CNRS Frenoble, France):Fungal lectins: targets and tools.

2016

  • 141. 4. november, Inštitut za biokemijo Medicinske fakultete v Ljubljani. prof. dr. Dan Cacsire Castillo-Tong (Medical University of Vienna, Austria):Molecular characterization of primary and recurrent high grade serous ovarian cancer.
  • 140. 4. julij, Soba B220 Inštitut Jožef Stefan. prof. dr. Daniel H. Wreschner (University Ramat Aviv, Israel):A new secreted protein expressed from the unknown and nameless gene C4orf48 acts as an angiogenic factor and comprises a novel signal peptide motif that marks several important secreted growth factors.
  • 139. 25. junij, Seminar Inštituta za biokemijo Medicinske fakultete v Ljubljani. dr. Csille Ozvegy-Laczka (Institute of enzymology, Hungarian Academy of Sciences):Functional assays for organic anion transporting polypeptides, transporters involved in drug ADME-Tox.
  • 138. 25. maj, Soba B220 Inštitut Jožef Stefan. dr. Tibor Hortobagyi (University of Debrecen, Hungary):Pathology and current molecular classification of ASL/FTD.

2015

  • 137. 25. september, Seminar Inštituta za biokemijo Medicinske fakultete v Ljubljani. Prof. dr. Rolf Gebhardt (Medical faculty, University of Lepzig, Germany):Liver and adipose tissue: a gain through mutual communication.
  • 136. 17. junij, Seminar Inštituta za biokemijo Medicinske fakultete v Ljubljani. prof. dr. Walter Jaeger (Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria):Interplay between cellular transport and metabolism of resveratrol: impact of therapy.
  • 135. 10. junij, Seminar Inštituta za biokemijo Medicinske fakultete v Ljubljani. doc. dr. Klementina Fon Tacer (UT Southwestern Dallas Medical Center, TX (USA)):Proteini MAGE - regulatorji E3 ubikvitinskih ligaz: vpogled v njihovo fiziološko vlogo in pomen pri nastanku raka.
  • 134. 18. maj, Seminar Inštituta za biokemijo Medicinske fakultete v Ljubljani. prof. dr. Gerold Baier (University College London, UK):Seizure rhythms - an introduction to computational neurology.
  • 133. 28. april, Preglova predavalnica Kemijskega inštituta v Ljubljani. prof. dr. Alvaro Martinez-del-Pozo (Universidad Complutense Madrid, Spain):Turning toxins into treatment.
  • 132. 20. februar, Seminar Inštituta za biokemijo Medicinske fakultete v Ljubljani. prof. dr. Winnie Eskild (University of Oslo, Norway):The Glmpgt/gt mouse - a new animal model of liver fibrosis.

2014

  • 131. 16. oktober, Seminar Inštituta za biokemijo Medicinske fakultete v Ljubljani. prof. dr. Theresie Thalhammer (Medical University of Vienna, Austria):Transmembrane transporters from the OATP family have an important role in cancer therapy.
  • 130. 10. oktober, Predavalnica Inštituta za biofiziko, Medicinska fakulteta v Ljubljani. prof. dr. Kelly Ryckman (University of Iowa, USA):Lipid and metabolic predictors of preterm birth.
  • 129. 23. september, Seminar Inštituta za biokemijo Medicinske fakultete v Ljubljani. Prof. dr. Elizabeth Ellis (University of Strathclyde, Glasgow, UK):Adaptive responses to reactive oxygen species: Can this be exploited in developing therapeutics for disease prevention?.
  • 128. 19. september, Predavalnica Mednarodne podiplomske šole Inštituta Jožef Stefan. Dr. Gerard Lambeau (CNRS and university of Nice Sophia Antipolis, France):Yin and Yang of secreted phospholipases A2 in host defence: focus on group IIA and X enzymes.
  • 127. 27. avgust, Velika predavalnica Kemijskega inštituta. Dr. Peter Greimel (Lipid Biology Laboratory, RIKEN, Saitama, Japan):A mushroom derived homologues of actinoporins - structural insights and substrate specificity.
  • 126. 4. april, Kemijski inštitut. Prof. dr. Oyvind Halskau (Department of Molecular Biology, University of Bergen, Norway):Relevance of the protein, fatty acid and lipid component in early stages of HAMLET-like cell death.
  • 125. 4. marec, Predavalnica B3, Biološko središče, Nacionalni inštitut za biologijo. prof. dr. Maria Luiza Viola (Departamento de Bioquimica, Universidade Federal de Sao Paulo, Brazil):A protein from plant source ECTI is highly selective for inhibition of mammalian enzyme playing a role as an anti-iflammatory, antithrombotic, and anti-tumor agent.

2013

  • 124. 26. november, Predavalnica Inštituta za biofiziko Medicinske fakultete v Ljubljani. prof. Michael Trauner (Division of Gastroenterology and Hepatology, Medical University of Vienna, Avstrija):Novel Hormonal Functions of Bile Acids.
  • 123. 12. november, Predavalnica Inštituta za biofiziko Medicinske fakultete v Ljubljani. prof. Gerold Baier (University College London, Anglija):SysMIC - a comprehensive eCourse for Systems Approaches in the Biosciences. Preberi več
  • 122. 24. oktober, Seminar Inštituta za biokemijo Medicinske fakultete . prof. Peter Solar (Institute of Biology and Ecology, Faculty of Sciences, P.J. Šafarik University, Košice, Slovaška):Erathropoietin receptor and ovarian cancer cells: from resistance to angiogenesis . Preberi več
  • 121. 4. april, Velika predavalnice, Kemijski inštitut. prof. F. Gisou van der Goot (Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL)):Swirling your way into the plasma membrane: the pore-forming toxin Aerolysin. Preberi več
  • 120. 29. marec, seminar Inštituta za biokemijo Medicinske fakultete. prof. Rolf Gebhardt (Institute of Biochemistry, Faculty of Medicine, University of Leipzig, Leipzig, Nemčija):Metabolic Zonation in the liver: key to unexpected functions of morphogens in homeostasis. Preberi več

2012

  • 119. 13. december, Velika predavalnica Kemijskega inštituta. Mark Wallace (Department of Chemistry, University of Oxford):Engineering Droplet Interface Bilayers for Single-Molecule Biology. Preberi več
  • 118. 22. oktober, Seminarska soba B220 na Institutu "Jožef Stefan". dr. Gérard Lambeau (Institute of Molecular and Cellular Pharmacology, CNRS and University of Nice Sophia Antipolis, France):Novel Functions of Secreted Phospholipases A2 and Their Receptor PLA2R1 in Human Pathophysiology. Preberi več
  • 117. 5. september, Mala predavalnica Medicinske fakultete, Univerze v Ljubljani, Korytkova ulica 2. prof. dr. Fred P. Guengerich (Vanderbilt University School of Medicine, Nashville, ZDA):Steroid oxidations by cytochrome P450 enzymes: Recent studies with P450 3A4, 7A1, 17A1, 19A1, & 21A2. Preberi več
  • 116. 20. avgust, Velika predavalnica Kemijskega inštituta, Hajdrihova 19, 1000 Ljubljana. Prof. dr. Toshihide Kobayashi (Lipid Biology Laboratory, RIKEN, Saitama 351-0198, Japan):Imaging Lipids and Lipid Domains. Preberi več
  • 115. 1. avgust, Velika predavalnica Kemijskega inštituta, Hajdrihova 19, 1000 Ljubljana. Dr. Andrej Bavdek (Membrane Traffic in Neuronal & Epithelial Morphogenesis (INSERM U950), Institut Jacques Monod (UMR 7592), Universite Paris 7):Molecular mechanisms orchestrating mitochondrial fusion. Preberi več
  • 114. 26. junij, Velika predavalnica Kemijskega inštituta, Hajdrihova 19, 1000 Ljubljana. Prof. dr. Frances Separovic (School of Chemistry, University of Melbourne, Australia ):NMR studies of antimicrobial and amyloid peptides. Preberi več
  • 113. 5. junij, Predavalnica pri Inštitutu za biofiziko Medicinska fakulteta, Univerza v Ljubljani, Vrazov trg 2 . Prof. Ulo Langel (Department of Neurochemistry, Stockholm University, Stockholm, Sweden):Cell-penetrating peptides in gene delivery. Preberi več
  • 112. 28. maj, Velika predavalnica; Kemijski inštitut, Hajdrihova 19, 1000 Ljubljana. Prof. dr. Shizuo Akira (Department of Host Defense, WPI Immunology Frontier Research Center, Osaka University):The role of LPS inducible genes, JMJD3 and zc3hq2a/regnase-1 in the immune response. Preberi več
  • 111. 7. maj, Predavalnica Inštituta za biofiziko Medicinske fakultete, Vrazov trg 2, Ljubljana. Dr. Katalin Monostory (Laboratory of Metabolic Drug-interactions, ResearCenter for Natural Sciences, Hungarian Academy of Sciences, Budimpešta, Madžarska):Personalized medication using CYPtestTM - Diagnostic approaches of drug-metabolizing capacity for personalized medication of transplant patients. Preberi več
  • 110. 13. april, Velika predavalnica; Kemijski inštitut, Hajdrihova 19, 1000 Ljubljana. Dr. Hanna Wacklin (European Spallation Source ESS AB, Lund, Sweden):Looking inside membranes: neutron reflection experiments on proteins and peptides. Preberi več
  • 109. 27. marec, Velika predavalnica; Kemijski inštitut, Hajdrihova 19, 1000 Ljubljana. Prof. dr. Sandhya S. Visweswariah (Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India):Signalling through receptor guanylyl cyclases: more than a 'gut' feeling. Preberi več
  • 108. 15. februar, Predavalnica B2; Biološko središče, Oddelek za biologijo, Biotehniška fakulteta, Univerza v Ljubljani, Večna pot 111, 1000 Ljubljana. Thorsten Nuernberger (University of Tübingen, Center for Plant Molecular Biology, Department Plant Biochemistry, Tübingen, Germany):Patterns and receptors in plant innate immunity. Preberi več

2011

  • 107. 12. september, Velika predavalnica Instituta "Jožef Stefan", Jamova 39, Ljubljana. Igor Vilfan (NGAT group, Pacific Biosciences, 1005 Hamilton Avenue, Menlo Park, CA 94025 ):Single-Molecule, Real-Time (SMRT™) Monitoring of Biomolecules: DNA Sequencing and Beyond. Preberi več
  • 106. 24. marec, Nova predavalnica, Fakulteta za kemijo in kemijsko tehnologijo, Univerza v Ljubljani. Ben Schuler (Department of Biochemistry, University of Zurich, Switzerland):Structure and dynamics in protein folding from single molecule fluorescence spectroscopy. Preberi več

2010

  • 105. 17. september, Oddelek za biologijo, Biotehniška fakulteta, Univerza v Ljubljani. Robert Gilbert (Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford):Cryo-EM as a tool in structural biology: advantages and pitfalls.
  • 104. 6. september, Oddelek za biologijo, Biotehniška fakulteta, Univerza v Ljubljani. Juan Gonzalez-Manas (Basque State University, Bilbao, Španija):The secret life of actinoporins.
  • 103. 11. februar, Inštitut Jožef Stefan. Igor Štagljar (University of Toronto, Kanada):Driving biological discoveries using the membrane yeast two-hybrid (myth) technology.

2009

  • 102. 5. oktober, Oddelek za biologijo, Biotehniška fakulteta, Univerza v Ljubljani. Jens Coorssen (University of Western Sidney, Australia):Perspectives and approaches to dissecting the mechanism of Ca2+-triggered membrane fusion.
  • 101. 4. september, Oddelek za biologijo, Biotehniška fakulteta, Univerza v Ljubljani. Lukas Tamm (University of Virginia, USA):Domain coupling in asymmetric bilayers and single molecule studies of fast SNARE-mediated membrane fusion .
  • 100. 18. junij, Kemijski inštitut. Senad Divanović (Cincinnati Childrens Hospital Medical Center, ZDA):The Toll road to obesity.
  • 99. 17. marec, Oddelek za biologijo, Biotehniška fakulteta, Univerza v Ljubljani. Andreas Werner (Institute for Cell and Molecular Biosciences, University of Newcastle upon Tyne):If sense takes a knock, is the antisense the answer? .

2008

  • 98. 3. november, Oddelek za biologijo, Biotehniška fakulteta, Univerza v Ljubljani. Alan Schulman (MTT & University of Helsinki, Finland):The role of retrotransposons in plant genome dynamics over gradients of space and time.
  • 97. 17. oktober, Inštitut za biokemijo, Medicinska fakulteta, Univerza v Ljubljani. Bernd Nidetzky (Institute of Biotechnology and Biochemical Engineering, Graz University of Technology):From structure-function relationships to biocatalytic applications of carbohydrate-processing enzymes.
  • 96. 30. september, Institut . Matej Orešič (Quantitative Biology and Bioinformatics Group, VTT, Espoo, Finska):Metabolic stress, autoimmunity & diabetes.
  • 95. 26. september, Oddelek za biologijo, Biotehniška fakulteta, Univerza v Ljubljani. Christopher J. Froelich (ENHRI, Evanston, IL, ZDA):The two faces of the cytotoxic cell granule secretion pathway.